Mavacamten decreases maximal force and Ca(2+) sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy

Morbidity and mortality associated with heart disease is a growing threat to the global population, and novel therapies are needed. Mavacamten (formerly called MYK-461) is a small molecule that binds to cardiac myosin and inhibits myosin ATPase. Mavacamten is currently in clinical trials for the tre...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Awinda, Peter O., Watanabe, Marissa, Bishaw, Yemeserach, Huckabee, Anna M., Agonias, Keinan B., Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Tanner, Bertrand C. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082789/
https://ncbi.nlm.nih.gov/pubmed/33337957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00345.2020
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