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Effects of mavacamten on Ca(2+) sensitivity of contraction as sarcomere length varied in human myocardium
BACKGROUND AND PURPOSE: Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca(2+) as cells are stretched. This represents a fundamental property of the myocardium that contributes to the Frank–Starling response,...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7707091/ https://ncbi.nlm.nih.gov/pubmed/32960449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15271 |
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