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A fork in the road: Where homologous recombination and stalled replication fork protection part ways

In response to replication hindrances, DNA replication forks frequently stall and are remodelled into a four-way junction. In such a structure the annealed nascent strand is thought to resemble a DNA double-strand break and remodelled forks are vulnerable to nuclease attack by MRE11 and DNA2. Protei...

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Foilsithe in:Semin Cell Dev Biol
Main Authors: Tye, Stephanie, Ronson, George E., Morris, Joanna R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Academic Press 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082280/
https://ncbi.nlm.nih.gov/pubmed/32653304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2020.07.004
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