NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

Antigen stimulation (signal 1) triggers B cell proliferation, and primes B cells to recruit, engage, and respond to T cell help (signal 2). Failure to receive signal 2 within a defined time window results in B cell apoptosis, yet the mechanisms that enforce dependence upon co-stimulation are incompl...

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Vydáno v:Nat Immunol
Hlavní autoři: Tan, Corey, Hiwa, Ryosuke, Mueller, James L., Vykunta, Vivasvan, Hibiya, Kenta, Noviski, Mark, Huizar, John, Brooks, Jeremy F., Garcia, Jose, Heyn, Cheryl, Li, Zhongmei, Marson, Alexander, Zikherman, Julie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081071/
https://ncbi.nlm.nih.gov/pubmed/32868928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0765-7
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