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Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells

B-1a cells are a unique population of innate-like B cells with a highly restricted and self-reactive BCR repertoire. Preimmune “natural” IgM produced by B-1a–derived plasma cells is essential for homeostatic clearance of cellular debris and forms a primary layer of protection against infection. In t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunohorizons
Prif Awduron: Huizar, John, Tan, Corey, Noviski, Mark, Mueller, James L., Zikherman, Julie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687085/
https://ncbi.nlm.nih.gov/pubmed/29152611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1700048
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