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Tight binding of cytochrome b(5) to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis
It has been recognized for >50 years that cytochrome b(5) (b(5)) stimulates some cytochrome P450 (P450)–catalyzed oxidations, but the basis of this function is still not understood well. The strongest stimulation of catalytic activity by b(5) is in the P450 17A1 lyase reaction, an essential step...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8080067/ https://ncbi.nlm.nih.gov/pubmed/33753170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100571 |
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