Structural and Kinetic Basis of Steroid 17α,20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2

Cytochrome P450 (P450) 17A enzymes play a critical role in the oxidation of the steroids progesterone (Prog) and pregnenolone (Preg) to glucocorticoids and androgens. In mammals, a single enzyme, P450 17A1, catalyzes both 17α-hydroxylation and a subsequent 17α,20-lyase reaction with both Prog and Pr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Pallan, Pradeep S., Nagy, Leslie D., Lei, Li, Gonzalez, Eric, Kramlinger, Valerie M., Azumaya, Caleigh M., Wawrzak, Zdzislaw, Waterman, Michael R., Guengerich, F. Peter, Egli, Martin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318999/
https://ncbi.nlm.nih.gov/pubmed/25533464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627265
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