Tight binding of cytochrome b(5) to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis

It has been recognized for >50 years that cytochrome b(5) (b(5)) stimulates some cytochrome P450 (P450)–catalyzed oxidations, but the basis of this function is still not understood well. The strongest stimulation of catalytic activity by b(5) is in the P450 17A1 lyase reaction, an essential step...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kim, Donghak, Kim, Vitchan, McCarty, Kevin D., Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080067/
https://ncbi.nlm.nih.gov/pubmed/33753170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100571
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