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Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis

The ciliate Tetrahymena thermophila can either synthesize tetrahymanol or when available, assimilate and modify sterols from its diet. This metabolic shift is mainly driven by transcriptional regulation of genes for tetrahymanol synthesis (TS) and sterol bioconversion (SB). The mechanistic details o...

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Publicado en:Sci Rep
Autores principales: Hernández, Josefina, Gabrielli, Matías, Costa, Joaquín, Uttaro, Antonio D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079401/
https://ncbi.nlm.nih.gov/pubmed/33907281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88737-z
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