Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells

BACKGROUND: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), i...

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Publicado en:Drug Des Devel Ther
Autores principales: Liu, Ping, Huang, Wen, Ding, Yirui, Wu, Jianbing, Liang, Zhuangzhuang, Huang, Zhangjian, Xie, Weiping, Kong, Hui
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2021
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076841/
https://ncbi.nlm.nih.gov/pubmed/33935492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S297500
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