Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

The expression of the bone morphogenetic protein antagonist, Gremlin 1, was recently shown to be increased in the lungs of pulmonary arterial hypertension patients, and in response to hypoxia. Gremlin 1 released from the vascular endothelium may inhibit endogenous bone morphogenetic protein signalin...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Ciuclan, Loredana, Sheppard, KellyAnn, Dong, Liqun, Sutton, Daniel, Duggan, Nicholas, Hussey, Martin, Simmons, Jenny, Morrell, Nicholas W., Jarai, Gabor, Edwards, Matthew, DuBois, Gerald, Thomas, Matthew, Van Heeke, Gino, England, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691347/
https://ncbi.nlm.nih.gov/pubmed/24160323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.07.017
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