The selective PGI(2) receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats

Pulmonary arterial hypertension (PAH) is a lethal disease characterized by a progressive increase in pulmonary artery pressure due to an increase in vessel tone and occlusion of vessels. The endogenous vasodilator prostacyclin and its analogs are used as therapeutic agents for PAH. However, their ph...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Honda, Yohei, Kosugi, Keiji, Fuchikami, Chiaki, Kuramoto, Kazuya, Numakura, Yuki, Kuwano, Keiichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561119/
https://ncbi.nlm.nih.gov/pubmed/33057388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240692
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