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The selective PGI(2) receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats

Pulmonary arterial hypertension (PAH) is a lethal disease characterized by a progressive increase in pulmonary artery pressure due to an increase in vessel tone and occlusion of vessels. The endogenous vasodilator prostacyclin and its analogs are used as therapeutic agents for PAH. However, their ph...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Honda, Yohei, Kosugi, Keiji, Fuchikami, Chiaki, Kuramoto, Kazuya, Numakura, Yuki, Kuwano, Keiichi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561119/
https://ncbi.nlm.nih.gov/pubmed/33057388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240692
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