Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells

BACKGROUND: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), i...

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Gepubliceerd in:Drug Des Devel Ther
Hoofdauteurs: Liu, Ping, Huang, Wen, Ding, Yirui, Wu, Jianbing, Liang, Zhuangzhuang, Huang, Zhangjian, Xie, Weiping, Kong, Hui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Dove 2021
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076841/
https://ncbi.nlm.nih.gov/pubmed/33935492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S297500
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