Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells

BACKGROUND: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), i...

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Bibliografiset tiedot
Julkaisussa:Drug Des Devel Ther
Päätekijät: Liu, Ping, Huang, Wen, Ding, Yirui, Wu, Jianbing, Liang, Zhuangzhuang, Huang, Zhangjian, Xie, Weiping, Kong, Hui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Dove 2021
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076841/
https://ncbi.nlm.nih.gov/pubmed/33935492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S297500
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