Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

BACKGROUND: There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release of mitochondrial DNA (mtDNA), but plasma cell-free mtDNA has not been previ...

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Pubblicato in:Respir Res
Autori principali: Zhang, William Z., Hoffman, Katherine L., Schiffer, Kristen T., Oromendia, Clara, Rice, Michelle C., Barjaktarevic, Igor, Peters, Stephen P., Putcha, Nirupama, Bowler, Russell P., Wells, J. Michael, Couper, David J., Labaki, Wassim W., Curtis, Jeffrey L., Han, Meilan K., Paine, Robert, Woodruff, Prescott G., Criner, Gerard J., Hansel, Nadia N., Diaz, Ivan, Ballman, Karla V., Nakahira, Kiichi, Choi, Mary E., Martinez, Fernando J., Choi, Augustine M. K., Cloonan, Suzanne M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8074408/
https://ncbi.nlm.nih.gov/pubmed/33902556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-021-01707-x
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