Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

BACKGROUND: Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly in various bodily fluids. Despite evidence for the increased prevalence of chro...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Zhang, William Z., Rice, Michelle C., Hoffman, Katherine L., Oromendia, Clara, Barjaktarevic, Igor Z., Wells, J. Michael, Hastie, Annette T., Labaki, Wassim W., Cooper, Christopher B., Comellas, Alejandro P., Criner, Gerard J., Krishnan, Jerry A., Paine, Robert, Hansel, Nadia N., Bowler, Russell P., Barr, R. Graham, Peters, Stephen P., Woodruff, Prescott G., Curtis, Jeffrey L., Han, Meilan K., Ballman, Karla V., Martinez, Fernando J., Choi, Augustine M.K., Nakahira, Kiichi, Cloonan, Suzanne M., Choi, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098791/
https://ncbi.nlm.nih.gov/pubmed/31895696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133984
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