Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

BACKGROUND: Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly in various bodily fluids. Despite evidence for the increased prevalence of chro...

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Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Zhang, William Z., Rice, Michelle C., Hoffman, Katherine L., Oromendia, Clara, Barjaktarevic, Igor Z., Wells, J. Michael, Hastie, Annette T., Labaki, Wassim W., Cooper, Christopher B., Comellas, Alejandro P., Criner, Gerard J., Krishnan, Jerry A., Paine, Robert, Hansel, Nadia N., Bowler, Russell P., Barr, R. Graham, Peters, Stephen P., Woodruff, Prescott G., Curtis, Jeffrey L., Han, Meilan K., Ballman, Karla V., Martinez, Fernando J., Choi, Augustine M.K., Nakahira, Kiichi, Cloonan, Suzanne M., Choi, Mary E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2020
Aiheet:
Clinical Medicine
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098791/
https://ncbi.nlm.nih.gov/pubmed/31895696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133984
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