Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition

SIMPLE SUMMARY: Mutations in RAS-family genes frequently cause different types of human cancers. Inhibitors of the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) protein kinases that function downstream of RAS proteins have shown some clinical benefits when us...

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Pubblicato in:Cancers (Basel)
Autori principali: Catalano, Antonella, Adlesic, Mojca, Kaltenbacher, Thorsten, Klar, Rhena F. U., Albers, Joachim, Seidel, Philipp, Brandt, Laura P., Hejhal, Tomas, Busenhart, Philipp, Röhner, Niklas, Zodel, Kyra, Fritsch, Kornelia, Wild, Peter J., Duyster, Justus, Fritsch, Ralph, Brummer, Tilman, Frew, Ian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8069437/
https://ncbi.nlm.nih.gov/pubmed/33924486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081852
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