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β(1)-adrenergic receptor N-terminal cleavage by ADAM17; the mechanism for redox-dependent downregulation of cardiomyocyte β(1)-adrenergic receptors

β(1)-adrenergic receptors (β(1)ARs) are the principle mediators of catecholamine action in cardiomyocytes. We previously showed that the β(1)AR extracellular N-terminus is a target for post-translational modifications that impact on signaling responses. Specifically, we showed that the β(1)AR N-term...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Zhu, Jing, Steinberg, Susan F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068644/
https://ncbi.nlm.nih.gov/pubmed/33556394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2021.01.012
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