Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

Normal hearts have increased contractility in response to catecholamines. Because several lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte responsiveness to adrenergic stimuli. Cardiomyocytes treated with saturated free fatty acids, ceramide, and diacylgl...

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Detalhes bibliográficos
Main Authors: Drosatos, Konstantinos, Bharadwaj, Kalyani G., Lymperopoulos, Anastasios, Ikeda, Shota, Khan, Raffay, Hu, Yunying, Agarwal, Rajiv, Yu, Shuiqing, Jiang, Hongfeng, Steinberg, Susan F., Blaner, William S., Koch, Walter J., Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064003/
https://ncbi.nlm.nih.gov/pubmed/21139071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00569.2010
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