Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

Normal hearts have increased contractility in response to catecholamines. Because several lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte responsiveness to adrenergic stimuli. Cardiomyocytes treated with saturated free fatty acids, ceramide, and diacylgl...

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Autori principali: Drosatos, Konstantinos, Bharadwaj, Kalyani G., Lymperopoulos, Anastasios, Ikeda, Shota, Khan, Raffay, Hu, Yunying, Agarwal, Rajiv, Yu, Shuiqing, Jiang, Hongfeng, Steinberg, Susan F., Blaner, William S., Koch, Walter J., Goldberg, Ira J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064003/
https://ncbi.nlm.nih.gov/pubmed/21139071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00569.2010
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