Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

Normal hearts have increased contractility in response to catecholamines. Because several lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte responsiveness to adrenergic stimuli. Cardiomyocytes treated with saturated free fatty acids, ceramide, and diacylgl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Drosatos, Konstantinos, Bharadwaj, Kalyani G., Lymperopoulos, Anastasios, Ikeda, Shota, Khan, Raffay, Hu, Yunying, Agarwal, Rajiv, Yu, Shuiqing, Jiang, Hongfeng, Steinberg, Susan F., Blaner, William S., Koch, Walter J., Goldberg, Ira J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2011
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064003/
https://ncbi.nlm.nih.gov/pubmed/21139071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00569.2010
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