PPARγ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality in Mice: Drosatos et al: PPARγ Treats Septic Cardiac Dysfunction

BACKGROUND: Cardiac dysfunction with sepsis is associated with both inflammation and reduced fatty acid oxidation (FAO). We hypothesized that energy deprivation accounts for sepsis-related cardiac dysfunction. METHODS AND RESULTS: E. coli lipopolysaccharide (LPS) administered to C57BL/6 mice (WT) in...

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Detalhes bibliográficos
Main Authors: Drosatos, Konstantinos, Khan, Raffay S., Trent, Chad M., Jiang, Hongfeng, Son, Ni-Huiping, Blaner, William S., Homma, Shunichi, Schulze, P. Christian, Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690188/
https://ncbi.nlm.nih.gov/pubmed/23572494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.000177
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