Mice with cardiac overexpression of PPARγ have impaired repolarization and spontaneous fatal ventricular arrhythmias (Morrow, PPARγ overexpression induces fatal arrhythmias)

BACKGROUND: Diabetes and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electrical properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of...

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Main Authors: Morrow, John P., Katchman, Alexander, Son, Ni-Huiping, Trent, Chad M., Khan, Raffay, Shiomi, Takayuki, Huang, Haiyan, Amin, Vaibhav, Lader, Joshua M., Vasquez, Carolina, Morley, Gregory E., D'Armiento, Jeanine, Homma, Shunichi, Goldberg, Ira J., Marx, Steven O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258098/
https://ncbi.nlm.nih.gov/pubmed/22124376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.056309
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