Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice

Three forms of PPARs are expressed in the heart. In animal models, PPARγ agonist treatment improves lipotoxic cardiomyopathy; however, PPARγ agonist treatment of humans is associated with peripheral edema and increased heart failure. To directly assess effects of increased PPARγ on heart function, w...

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Detalhes bibliográficos
Main Authors: Son, Ni-Huiping, Park, Tae-Sik, Yamashita, Haruyo, Yokoyama, Masayoshi, Huggins, Lesley A., Okajima, Kazue, Homma, Shunichi, Szabolcs, Matthias J., Huang, Li-Shin, Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964508/
https://ncbi.nlm.nih.gov/pubmed/17823655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30335
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