Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly

Synaptic vesicle fusion is mediated by SNARE proteins - VAMP2 on the vesicle and Syntaxin-1/SNAP25 on the pre-synaptic membrane. Chaperones Munc18–1 and Munc13–1 co-operatively catalyze SNARE assembly via an intermediate ‘template’ complex containing Syntaxin-1 and VAMP2. How SNAP25 enters this reac...

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Bibliographic Details
Published in:FEBS Lett
Main Authors: Sundaram, R Venkat Kalyana, Jin, Huaizhou, Li, Feng, Shu, Tong, Coleman, Jeff, Yang, Jie, Pincet, Frederic, Zhang, Yongli, Rothman, James E., Krishnakumar, Shyam S.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068094/
https://ncbi.nlm.nih.gov/pubmed/33222163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.14006
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