Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

The T cell antigen receptor (TCR) is expressed on T cells, which orchestrate adaptive immune responses. It is composed of the ligand-binding clonotypic TCRαβ heterodimer and the non-covalently bound invariant signal-transducing CD3 complex. Among the CD3 subunits, the CD3ε cytoplasmic tail contains...

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Publicat a:Cells
Autors principals: Hartl, Frederike A., Ngoenkam, Jatuporn, Beck-Garcia, Esmeralda, Cerqueira, Liz, Wipa, Piyamaporn, Paensuwan, Pussadee, Suriyaphol, Prapat, Mishra, Pankaj, Schraven, Burkhart, Günther, Stefan, Pongcharoen, Sutatip, Schamel, Wolfgang W. A., Minguet, Susana
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068026/
https://ncbi.nlm.nih.gov/pubmed/33917227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10040834
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