Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor

T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials. The anti-CD3ε antibody UCHT1 enhanced the in vitro tumor killing activity of human γδ T cell...

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Publicat a:Front Immunol
Autors principals: Juraske, Claudia, Wipa, Piyamaporn, Morath, Anna, Hidalgo, Jose Villacorta, Hartl, Frederike A., Raute, Katrin, Oberg, Hans-Heinrich, Wesch, Daniela, Fisch, Paul, Minguet, Susana, Pongcharoen, Sutatip, Schamel, Wolfgang W.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046647/
https://ncbi.nlm.nih.gov/pubmed/30038626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01579
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