Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a

In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative regulator of p53. We evaluated PPM1D expression and explored the therapeutic efficacy of WIP1 inhibitor (WIP1i) GSK2830371, in...

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Bibliografiset tiedot
Julkaisussa:Biomedicines
Päätekijät: Fontana, Maria Chiara, Nanni, Jacopo, Ghelli Luserna di Rorà, Andrea, Petracci, Elisabetta, Padella, Antonella, Ghetti, Martina, Ferrari, Anna, Marconi, Giovanni, Soverini, Simona, Iacobucci, Ilaria, Papayannidis, Cristina, Curti, Antonio, Audisio, Ernesta, Giannini, Maria Benedetta, Rondoni, Michela, Lanza, Francesco, Cavo, Michele, Martinelli, Giovanni, Simonetti, Giorgia
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067413/
https://ncbi.nlm.nih.gov/pubmed/33917342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9040388
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