Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a

In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative regulator of p53. We evaluated PPM1D expression and explored the therapeutic efficacy of WIP1 inhibitor (WIP1i) GSK2830371, in...

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Publicado en:Biomedicines
Main Authors: Fontana, Maria Chiara, Nanni, Jacopo, Ghelli Luserna di Rorà, Andrea, Petracci, Elisabetta, Padella, Antonella, Ghetti, Martina, Ferrari, Anna, Marconi, Giovanni, Soverini, Simona, Iacobucci, Ilaria, Papayannidis, Cristina, Curti, Antonio, Audisio, Ernesta, Giannini, Maria Benedetta, Rondoni, Michela, Lanza, Francesco, Cavo, Michele, Martinelli, Giovanni, Simonetti, Giorgia
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067413/
https://ncbi.nlm.nih.gov/pubmed/33917342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9040388
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