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Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients
MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investigate the preclinical activity of the MDM2 antagonist, Nutlin-3a, in Philadelphia positive (Ph(+)) and negative (Ph(−)) leukemic cell line models, and primary B-acute lymphoblastic leukemia (ALL) patie...
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| Udgivet i: | Oncotarget |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914334/ https://ncbi.nlm.nih.gov/pubmed/26887044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7339 |
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