Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investigate the preclinical activity of the MDM2 antagonist, Nutlin-3a, in Philadelphia positive (Ph(+)) and negative (Ph(−)) leukemic cell line models, and primary B-acute lymphoblastic leukemia (ALL) patie...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Trino, Stefania, Iacobucci, Ilaria, Erriquez, Daniela, Laurenzana, Ilaria, De Luca, Luciana, Ferrari, Anna, Luserna Di Rorà, Andrea Ghelli, Papayannidis, Cristina, Derenzini, Enrico, Simonetti, Giorgia, Lonetti, Annalisa, Venturi, Claudia, Cattina, Federica, Ottaviani, Emanuela, Abbenante, Maria Chiara, Russo, Domenico, Perini, Giovanni, Musto, Pellegrino, Martinelli, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914334/
https://ncbi.nlm.nih.gov/pubmed/26887044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7339
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