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P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia

The tumor suppressor p53 is a canonical regulator of different biological functions, like apoptosis, cell cycle arrest, DNA repair, and genomic stability. This gene is frequently altered in human tumors generally by point mutations or deletions. Conversely, in acute lymphoblastic leukemia (ALL) geno...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Trino, Stefania, De Luca, Luciana, Laurenzana, Ilaria, Caivano, Antonella, Del Vecchio, Luigi, Martinelli, Giovanni, Musto, Pellegrino
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159974/
https://ncbi.nlm.nih.gov/pubmed/28018226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00491
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