P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia

The tumor suppressor p53 is a canonical regulator of different biological functions, like apoptosis, cell cycle arrest, DNA repair, and genomic stability. This gene is frequently altered in human tumors generally by point mutations or deletions. Conversely, in acute lymphoblastic leukemia (ALL) geno...

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Vydáno v:Front Pharmacol
Hlavní autoři: Trino, Stefania, De Luca, Luciana, Laurenzana, Ilaria, Caivano, Antonella, Del Vecchio, Luigi, Martinelli, Giovanni, Musto, Pellegrino
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159974/
https://ncbi.nlm.nih.gov/pubmed/28018226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00491
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