Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice

OBJECTIVE: Cytoskeletal structural proteins maintain cell structural integrity by bridging extracellular matrix (ECM) with contractile filaments. During AAA development, (i) aortic medial degeneration is associated with loss of smooth muscle cell (SMC) integrity, and (ii) fibrogenic mesenchymal cell...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Muniappan, Latha, Okuyama, Michihiro, Javidan, Aida, Thiagarajan, Devi, Jiang, Weihua, Moorleghen, Jessica J., Yang, Lihua, Balakrishnan, Anju, Howatt, Deborah A., Uchida, Haruhito A., Saido, Takaomi C., Subramanian, Venkateswaran
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062307/
https://ncbi.nlm.nih.gov/pubmed/33761765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315546
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