Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice

BACKGROUND AND OBJECTIVE: Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice. In addition, pharmacological inhibition of calpain attenuated AngII-induced abdominal aortic aneu...

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Main Authors: Subramanian, Venkateswaran, Moorleghen, Jessica J., Balakrishnan, Anju, Howatt, Deborah A., Chishti, Athar H., Uchida, Haruhito A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747148/
https://ncbi.nlm.nih.gov/pubmed/23977256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072214
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