Leukocyte Calpain Deficiency Reduces Angiotensin II-induced Inflammation and Atherosclerosis but not Abdominal Aortic Aneurysms in Mice

OBJECTIVE: Angiotensin II (AngII)-infusion profoundly increases activity of calpains, calcium-dependent neutral cysteine proteases, in mice. Pharmacological inhibition of calpains attenuates AngII-induced aortic medial macrophage accumulation, atherosclerosis, and abdominal aortic aneurysm in mice....

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Howatt, Deborah A., Balakrishnan, Anju, Moorleghen, Jessica J., Muniappan, Latha, Rateri, Debra L., Uchida, Haruhito A., Takano, Jiro, Saido, Takaomi C., Chishti, Athar H., Baud, Laurent, Subramanian, Venkateswaran
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850100/
https://ncbi.nlm.nih.gov/pubmed/26966280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307285
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