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Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue
The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting small molecules that function as displacement activato...
שמור ב:
| הוצא לאור ב: | Front Aging Neurosci |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Frontiers Media S.A.
2021
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8060438/ https://ncbi.nlm.nih.gov/pubmed/33897412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.673205 |
| תגים: |
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