Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting small molecules that function as displacement activato...

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Bibliografske podrobnosti
izdano v:Front Aging Neurosci
Main Authors: Hushpulian, Dmitry M., Ammal Kaidery, Navneet, Ahuja, Manuj, Poloznikov, Andrey A., Sharma, Sudarshana M., Gazaryan, Irina G., Thomas, Bobby
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060438/
https://ncbi.nlm.nih.gov/pubmed/33897412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.673205
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