XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment

Single-cell RNA sequencing (scRNA-seq) of tissues has revealed remarkable heterogeneity of cell types and states but does not provide information on the spatial organization of cells. To better understand how individual cells function within an anatomical space, we developed XYZeq, a workflow that e...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Lee, Youjin, Bogdanoff, Derek, Wang, Yutong, Hartoularos, George C., Woo, Jonathan M., Mowery, Cody T., Nisonoff, Hunter M., Lee, David S., Sun, Yang, Lee, James, Mehdizadeh, Sadaf, Cantlon, Joshua, Shifrut, Eric, Ngyuen, David N., Roth, Theodore L., Song, Yun S., Marson, Alexander, Chow, Eric D., Ye, Chun Jimmie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059935/
https://ncbi.nlm.nih.gov/pubmed/33883145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4755
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