Pooled Knock-In Targeting for Genome Engineering of Cellular Immunotherapies

Adoptive transfer of genetically-modified immune cells holds great promise for cancer immunotherapy. CRISPR knock-in targeting can improve cell therapies, but more high-throughput methods are needed to test which knock-in gene constructs most potently enhance primary cell functions in vivo. We devel...

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Pubblicato in:Cell
Autori principali: Roth, Theodore L., Li, P. Jonathan, Blaeschke, Franziska, Nies, Jasper F., Apathy, Ryan, Mowery, Cody, Yu, Ruby, Nguyen, Michelle L.T., Lee, Youjin, Truong, Anna, Hiatt, Joseph, Wu, David, Nguyen, David N., Goodman, Daniel, Bluestone, Jeffrey A., Ye, Chun Jimmie, Roybal, Kole, Shifrut, Eric, Marson, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219528/
https://ncbi.nlm.nih.gov/pubmed/32302591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.03.039
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