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RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x(L) in developing thymocytes

The cytokine receptor subunit γc provides critical signals for T cell survival and differentiation. We investigated the molecular mechanism that controls the cell surface abundance of γc during T cell development in the thymus. We found that the amount of γc was low on CD4(+)CD8(+) double-positive (...

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Pubblicato in:Sci Signal
Autori principali: Ligons, Davinna L., Hwang, SuJin, Waickman, Adam T., Park, Joo-Young, Luckey, Megan A., Park, Jung-Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058635/
https://ncbi.nlm.nih.gov/pubmed/30154103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aam8939
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