Activated T cells secrete an alternatively spliced form of γc that inhibits cytokine signaling and exacerbates inflammatory autoimmune disease

The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc–dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of γc mRNA that results in protein expression and secretion of the γc extracellular domain. The soluble form of γc (sγc) is...

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Hlavní autoři: Hong, Changwan, Luckey, Megan A., Ligons, Davinna L., Waickman, Adam T., Park, Joo-Young, Kim, Grace Y., Keller, Hilary R., Etzensperger, Ruth, Tai, Xuguang, Lazarevic, Vanja, Feigenbaum, Lionel, Catalfamo, Marta, Walsh, Scott T. R., Park, Jung-Hyun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143255/
https://ncbi.nlm.nih.gov/pubmed/24909888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.020
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