Activated T cells secrete an alternatively spliced form of γc that inhibits cytokine signaling and exacerbates inflammatory autoimmune disease

The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc–dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of γc mRNA that results in protein expression and secretion of the γc extracellular domain. The soluble form of γc (sγc) is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hong, Changwan, Luckey, Megan A., Ligons, Davinna L., Waickman, Adam T., Park, Joo-Young, Kim, Grace Y., Keller, Hilary R., Etzensperger, Ruth, Tai, Xuguang, Lazarevic, Vanja, Feigenbaum, Lionel, Catalfamo, Marta, Walsh, Scott T. R., Park, Jung-Hyun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143255/
https://ncbi.nlm.nih.gov/pubmed/24909888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.020
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