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Pim1 permits generation and survival of CD4(+) T cells in the absence of γc cytokine receptor signaling
γc cytokine receptor signaling is required for the development of all lymphocytes. Why γc signaling plays such an essential role is not fully understood, but induction of the serine/threonine kinase Pim1 is considered a major downstream event of γc as Pim1 prevents apoptosis and increases metabolic...
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| Publié dans: | Eur J Immunol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7394666/ https://ncbi.nlm.nih.gov/pubmed/23712827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242686 |
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