Sumoylation of RORγt regulates T(H)17 differentiation and thymocyte development

RORγt controls the differentiation of T(H)17 cells, which are mediators of autoimmune conditions such as experimental autoimmune encephalomyelitis (EAE). RORγt also regulates thymocyte development and lymph node genesis. Here we show that the function of RORγt is regulated by its sumoylation. Loss o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: He, Zhiheng, Zhang, Jing, Huang, Zhaofeng, Du, Qian, Li, Ning, Zhang, Qiang, Chen, Yuan, Sun, Zuoming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242824/
https://ncbi.nlm.nih.gov/pubmed/30451821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07203-z
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