Two amino acid mutation disrupts RORγt function in Th17 differentiation but not thymocyte development

RORγt regulates T(H)17 differentiation, thymic T cell development and lymph node genesis. Although elimination of RORγt prevents T(H)17-mediated experimental autoimmune encephalomyelitis (EAE), it also disrupts thymocyte development, which could lead to lethal thymic lymphoma. Here we identified two...

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Gepubliceerd in:Nat Immunol
Hoofdauteurs: He, Zhiheng, Ma, Jian, Wang, Ruiqing, Zhang, Jing, Huang, Zhaofeng, Wang, Fei, Sen, Subha, Rothenberg, Ellen V., Sun, Zuoming
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678981/
https://ncbi.nlm.nih.gov/pubmed/28846085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3832
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