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HDAC3 is required for the down-regulation of RORγt during thymocyte positive selection
To generate functional peripheral T cells, proper gene regulation during T cell development is critical. Here, we found that histone deacetylase 3 (HDAC3) is required for T cell development. T cell development in CD2-icre HDAC3 conditional knockout mice (HDAC3-cKO) was blocked at positive selection,...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940140/ https://ncbi.nlm.nih.gov/pubmed/27279370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502529 |
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