HDAC3 is required for the down-regulation of RORγt during thymocyte positive selection

To generate functional peripheral T cells, proper gene regulation during T cell development is critical. Here, we found that histone deacetylase 3 (HDAC3) is required for T cell development. T cell development in CD2-icre HDAC3 conditional knockout mice (HDAC3-cKO) was blocked at positive selection,...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Philips, Rachael L., Chen, Meibo W., McWilliams, Douglas C., Belmonte, Paul J., Constans, Megan M., Shapiro, Virginia Smith
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940140/
https://ncbi.nlm.nih.gov/pubmed/27279370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502529
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