Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins G(s) (stimulatory) and G(i) (inhibitory) and several arrestin proteins. The...

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Vydáno v:Nature
Hlavní autoři: Kang, Yanyong, Kuybeda, Oleg, de Waal, Parker W., Mukherjee, Somnath, Van Eps, Ned, Dutka, Przemyslaw, Zhou, X. Edward, Bartesaghi, Alberto, Erramilli, Satchal, Morizumi, Takefumi, Gu, Xin, Yin, Yanting, Liu, Ping, Jiang, Yi, Meng, Xing, Zhao, Gongpu, Melcher, Karsten, Ernst, Oliver P., Kossiakoff, Anthony A., Subramaniam, Sriram, Xu, H. Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054211/
https://ncbi.nlm.nih.gov/pubmed/29899450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0215-y
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