Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins G(s) (stimulatory) and G(i) (inhibitory) and several arrestin proteins. The...

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Gepubliceerd in:Nature
Hoofdauteurs: Kang, Yanyong, Kuybeda, Oleg, de Waal, Parker W., Mukherjee, Somnath, Van Eps, Ned, Dutka, Przemyslaw, Zhou, X. Edward, Bartesaghi, Alberto, Erramilli, Satchal, Morizumi, Takefumi, Gu, Xin, Yin, Yanting, Liu, Ping, Jiang, Yi, Meng, Xing, Zhao, Gongpu, Melcher, Karsten, Ernst, Oliver P., Kossiakoff, Anthony A., Subramaniam, Sriram, Xu, H. Eric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054211/
https://ncbi.nlm.nih.gov/pubmed/29899450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0215-y
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