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X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10

Histone deacetylase 10 (HDAC10) is a zinc-dependent polyamine deacetylase enriched in the cytosol of eukaryotic cells. The active site of HDAC10 contains catalytic residues conserved in other HDAC isozymes that function as lysine deacetylases: Y307 assists the zinc ion in polarizing the substrate ca...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Herbst-Gervasoni, Corey J., Christianson, David W.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053227/
https://ncbi.nlm.nih.gov/pubmed/33449614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00936
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