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Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
Both adenine base editors (ABEs) and cytosine base editors (CBEs) have been recently revealed to induce transcriptome-wide RNA off-target editing in a guide RNA-independent manner. Here we construct a reporter system containing E.coli Hokb gene with a tRNA-like motif for robust detection of RNA edit...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052359/ https://ncbi.nlm.nih.gov/pubmed/33863894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22519-z |
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