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Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences
BACKGROUND: Site-specific C>T DNA base editing has been achieved by recruiting cytidine deaminases to the target C using catalytically impaired Cas proteins; the target C is typically located within 5-nt editing window specified by the guide RNAs. The prototypical cytidine base editor BE3, compri...
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| 出版年: | BMC Biol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7893952/ https://ncbi.nlm.nih.gov/pubmed/33602235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00879-0 |
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