Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation

Traditional CRISPR/Cas9-based gene knockouts are generated by introducing DNA double-strand breaks (DSBs), but this may cause excessive DNA damage or cell death. CRISPR-based cytosine base editors (CBEs) and adenine base editors (ABEs) can facilitate C-to-T or A-to-G exchanges, respectively, without...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Wang, Xinjie, Liu, Zhiwei, Li, GuangLei, Dang, Lu, Huang, Shisheng, He, Lei, Ma, Yu’e, Li, Cong, Liu, Ming, Yang, Guang, Huang, Xingxu, Zhou, Fei, Ma, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001054/
https://ncbi.nlm.nih.gov/pubmed/31843453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.022
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